If you’ve benefitted from the medications Ozempic, Wegovy, and others like them to treat diabetes and support weight management, thank the Gila monster. They have a hormone (exendin-4) that controls their blood sugar and delays the stomach from emptying, prolonging feelings of fullness. It’s similar in chemical composition to our GLP-1 hormone that performs the same functions in our bodies. However, the Gila monster’s exendin-4 allows them to stay healthy while eating only 5 to 10 times per year.
This ability to fast for long periods of time without impacting their health piqued the interest of endocrinologist Dr. John Eng and his team of researchers in the 1980s and 1990s. They set out to discover if a medication that mimics exendin-4 would help humans manage their blood sugar and weight.
A component of their venom, the Gila monster’s exendin-4 while similar to our GLP-1 was found by Eng and his team to be effective for much longer. In clinical trials, one injection of a medication inspired by exendin-4 helped diabetics keep their blood sugar under control for an entire week and decreased their appetite, helping them to lose weight, too.
Though it took decades of testing and evaluation, exenatide, a synthetic version of exendin-4 was approved by the FDA in 2005 to treat Type-2 diabetes. Research continued to evaluate it as a treatment for obesity and weight management. That research led the creation of semaglutide, the active ingredient in the drugs Ozempic and Wegovy.
Gila monsters are our elders. They trace their ancestry back to the Cretaceous period when dinosaurs ruled the planet, 145 – 66 million years ago, nearly 60 million years before our earliest ancestors made an appearance. Gila monsters are in essence “living fossils”. In that time, they evolved astounding abilities that weāre just beginning to fully understand.
Unfortunately, this creature who survived the catastrophic asteroid that wiped out the dinosaurs is steadily being wiped out by us. Their population is declining due to the pet trade and the destruction of habitat from agriculture and urbanization despite the fact that without them, the multi-billion-dollar drugs Ozempic, Wegovy, and others wouldn’t exist.
Nature, and the species with whom we share this one planet, are intricately tied to our health and well-being. Stories like that of the Gila monster and Ozempic remind us that nature is a research lab, pharmacy, archive, library, concert hall, and constant source of inspiration. When we threaten the lives of other species, we compromise our own opportunities to live well. There’s no getting around it: We are a part of nature, not apart from nature. How bright our future will be depends on how much we respect and safeguard the natural world, and the health of the ecosystems within which we all live.
Christa Avampato 